منابع مشابه
Azacitidine after allo-SCT: the good without the bad?
In allo-SCT, the potential benefit of the GVL effect has always been offset by the detrimental effect of GVHD. For more than 4 decades, separation between GVHD and GVL remained challenging and has been considered the Holy Grail in the field of allo-SCT. Several direct and indirect lines of evidence already suggested a close correlation between GVHD and the risk of relapse after allo-SCT.2 Donor...
متن کاملIncreased expression of granzymes A and B in fatal asthma.
The granules of effector cytotoxic CD8 cells and natural killer (NK) cells contain a family of serine proteases called granzymes (granule-secreted enzymes) [5]. Granzymes are stored in the cytotoxic granules and require perforin to be delivered into the target cells to exert their cytotoxic function [5, 6]. Granzymes can also be released to the extracellular space and cleave extracellular matri...
متن کاملIncreased expression of granzymes A and B in fatal asthma
The granules of effector cytotoxic CD8 cells and natural killer (NK) cells contain a family of serine proteases called granzymes (granule-secreted enzymes) [5]. Granzymes are stored in the cytotoxic granules and require perforin to be delivered into the target cells to exert their cytotoxic function [5, 6]. Granzymes can also be released to the extracellular space and cleave extracellular matri...
متن کاملOutcomes of Allogeneic Stem Cell Transplant (allo-SCT) Recipients in the Era of Newer Antifungal Agents
© ISDS Annual Conference Proceedings 2013. This is an Open Access article distributed under the terms of the Creative Commons Attribution-Noncommercial 3.0 Unported License ( http://creativecommons.org/licenses/by-nc/3.0/), which permits distribution, public display, and publicly performance, making multiple copies, distribution of derivative works, provided the original work is properly cited....
متن کاملNKp46 expression on NK cells as a prognostic and predictive biomarker for response to allo-SCT in patients with AML
NKp46 is a major determinant of natural killer (NK) cell function and it is implicated in tumor immune surveillance in acute myeloid leukemia (AML). The purpose of this study was to investigate the prognostic significance of NKp46 expression in an independent cohort of patients with AML, and to investigate the impact of NKp46 on clinical outcome after allogeneic stem cell transplantation (allo-...
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ژورنال
عنوان ژورنال: Bone Marrow Transplantation
سال: 2008
ISSN: 0268-3369,1476-5365
DOI: 10.1038/bmt.2008.395